The designed core-shell microcapsules showed a high cell viability during the culture procedure. Here, we developed a novel core-shell microcapsule with a stem cell-laden core and a biomass shell by using all-aqueous phase microfluidic electrospray technology. The attempts to develop this therapeutic approach focus on the generation of effective cell delivery vehicles, since the shortcomings of direct injection of stem cells into target tissues. Stem cell transplantation has emerged as an alternative approach for bone repair and attracted widespread attention owing to its excellent biological activities and therapy effect. Bone defects caused by trauma, tumor, or osteoarthritis remain challenging due to the lack of effective treatments in clinic.
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